SUPEROXIDE DISMUT 1; RB X HU-50UL

Application

Western blotting: 1:500

Optimal working dilutions must be determined by end user.

Anti-Superoxide Dismutase 1 Antibody, aa 25-37 detects level of Superoxide Dismutase 1 & has been published & validated for use in WB.

General description

Mutations in the copper/ zinc superoxide dismutase (SOD1) gene are associated with 15- 20% of the familial forms of motoneuron disease. This 153 amino acid metalloenzyme is expressed in virtually all cells of all organisms above bacteria and is highly conserved across species, although some minor variations do occur. The incorporation of the mutated form of the SOD1 human gene into a transgenic mouse leads to the onset of the disease that closely resembles the human condition. These animals become weak at about 2-4 months of age and rapidly lose function, which results in death 4- 6 weeks later.

Immunogen

Epitope: aa 25-37

Synthetic peptide corresponding to amino acids 25-37 of human SOD1.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Specificity

Superoxide Dismutase 1 (SOD1), human specific.

Storage and Stability

Maintain lyophilized material at -70°C (dry) for up to 12 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.